Inglourious Basterds begins in German-occupied France, where Shoshanna Dreyfus (Mélanie Laurent) witnesses the execution of her family at the hand of Nazi Colonel Hans Landa (Christoph Waltz). Shosanna narrowly escapes and flees to Paris, where she forges a new identity as the owner and operator of a cinema.

Elsewhere in Europe, Lieutenant Aldo Raine (Brad Pitt) organizes a group of Jewish soldiers to engage in targeted acts of retribution. Known to their enemy as "The Basterds," Raine's squad joins German actress and undercover agent Bridget Von Hammersmark (Diane Kruger) on a mission to take down the leaders of The Third Reich. Fates converge under a cinema marquee, where Shosanna is poised to carry out a revenge plan of her own..."

Tarantino's international cast includes Brad Pitt, Diane Kruger, Mike Myers, Eli Roth, Cloris Leachman, Rod Taylor, Daniel Brühl (The Edukators), Samm Levine (Freaks and Geeks), Til Schweiger (King Arthur), B.J. Novak (The Office), Michael Fassbender (300), Mélanie Laurent (Days of Glory), Michael Bacall (Death Proof), Omar Doom (Death Proof), Julie Dreyfus (Kill Bill Vol. 1), August Diehl (The Counterfeiters), Richard Sammel (Casino Royale), Christian Berkel (Black Book), and more. The film reunites Tarantino with Kill Bill Vol. 1 and 2 cinematographer Bob Richardson, longtime production designer David Wasco, Oscar-nominated editor Sally Menke (Pulp Fiction), and producer Lawrence Bender.